Yes, you can. Whenever you use buttermilk, add baking soda to your cake batter because it neutralizes the bitter taste of buttermilk.
Why you should use BUTTERMILK for baking and how to make it yourself at home!
FAQ
What happens if you substitute buttermilk for milk?
Yes, you can replace milk with an equal amount of buttermilk, but it will affect the flavor and acidity. The flavor won’t be bad, just sharper. Take the difference between buttermilk and regular pancakes, for example.
How do I substitute buttermilk for milk in a cake?
Tip: To substitute buttermilk for milk in a recipe, use 2 teaspoons less baking powder and 1/2 teaspoon more baking soda than called for in the recipe for every cup of buttermilk used. Baking with Sour Cream: The creamy texture of sour cream makes baked goods more moist than if you used milk.
Can you use buttermilk instead of milk in coffee?
Buttermilk. Despite the way it sounds, buttermilk is neither sweet nor creamy — it actually tends to be quite bitter. It has a slightly thick consistency, similar to eggnog, and we do not recommend adding it to coffee of any sort. Buttermilk is much better for baking rather than drinking.